Structural highlights
4jqw is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | |
| NonStd Res: | |
| Related: | 2nsn, 2nz7, 4e9m, 1ubq, 2o6v, 1aar |
| Gene: | CARD4, NOD1 (HUMAN), UBC (HUMAN) |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
The Caspase Recruitment Domain (CARD) from the innate immune receptor NOD1 was crystallized with Ubiquitin (Ub). NOD1 CARD was present as a helix-swapped homodimer similar to other structures of NOD1 CARD, and Ub monomers formed a homodimer similar in conformation to Lys48-linked di-Ub. The interaction between NOD1 CARD and Ub in the crystal was mediated by novel binding sites on each molecule. Comparisons of these sites to previously identified interaction surfaces on both molecules were made along with discussion of their potential functional significance.
Crystal structure of a complex of NOD1 CARD and ubiquitin.,Ver Heul AM, Gakhar L, Piper RC, Subramanian R PLoS One. 2014 Aug 15;9(8):e104017. doi: 10.1371/journal.pone.0104017., eCollection 2014. PMID:25127239[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Ver Heul AM, Gakhar L, Piper RC, Subramanian R. Crystal structure of a complex of NOD1 CARD and ubiquitin. PLoS One. 2014 Aug 15;9(8):e104017. doi: 10.1371/journal.pone.0104017., eCollection 2014. PMID:25127239 doi:http://dx.doi.org/10.1371/journal.pone.0104017
