3pz2

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Template:STRUCTURE 3pz2

Contents 1 Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP 2 Function 3 About this Structure 4 Reference

Crystal structure of RabGGTase(DELTA LRR; DELTA IG) in Complex with BMS3 and lipid substrate GGPP

Function

[PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively. [PGTB2_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.

About this Structure

3pz2 is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

Reference

• Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov K, Blankenfeldt W, Goody RS, Waldmann H. Structure-Guided Development of Selective RabGGTase Inhibitors. Angew Chem Int Ed Engl. 2011 May 16;50(21):4957-61. doi:, 10.1002/anie.201101210. Epub 2011 Apr 21. PMID:21520375 doi:10.1002/anie.201101210