This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2j9a
From Proteopedia
|
BLLAP IN COMPLEX WITH MICROGININ FR1
Overview
Natural bioactive compounds are of general interest for pharmaceutical, research because they may serve as leads in drug development campaigns., Among them, microginins are linear peptides known to inhibit various, exopeptidases. The crystal structure of microginin FR1 from Microcystis, sp. bound to bovine lens leucine aminopeptidase was established at 1.73, Angstrom resolution. The observed binding structure could be beneficial, for the design of potent aminopeptidase inhibitors.
About this Structure
2J9A is a [Single protein] structure of sequence from [Bos taurus] and [Microcystis sp.] with CL, ZN, DMS, AHY and MPD as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:17157838
Page seeded by OCA on Tue Oct 30 17:27:32 2007
Categories: Bos taurus | Microcystis sp. | Single protein | Kraft, M. | Schleberger, C. | Schulz, G.E. | Weckesser, J. | AHY | CL | DMS | MPD | ZN | Acetylation | Aminopeptidase | Inhibitor complex hydrolase | Leucine aminopeptidase | Metal-binding | Microcystins | Microginin | Protease
