4j93

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Template:STRUCTURE 4j93

Contents

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BI-1

Template:ABSTRACT PUBMED 23817385

Function

[Q79791_9HIV1] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS000071_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS000071_004_011858]

About this Structure

4j93 is a 1 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

  • Lamorte L, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW. Discovery of Novel Small Molecule HIV-1 Replication Inhibitors that Stabilize Capsid Complexes. Antimicrob Agents Chemother. 2013 Jul 1. PMID:23817385 doi:10.1128/AAC.00985-13

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