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Template:STRUCTURE 4at7

Contents 1 Crystal structure of the NF90-NF45 dimerisation domain complex 2 Function 3 About this Structure 4 Reference

Crystal structure of the NF90-NF45 dimerisation domain complex

Template:ABSTRACT PUBMED 22833610

Function

[ILF2_MOUSE] Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity).^[1] [ILF3_MOUSE] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity).

About this Structure

4at7 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

1. ↑ Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH. Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity. J Biol Chem. 1999 Dec 3;274(49):34598-604. PMID:10574923