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4bx0

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Revision as of 10:14, 25 December 2013 by OCA (Talk | contribs)
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Template:STRUCTURE 4bx0

Contents

Crystal Structure of a Monomeric Variant of murine Chronophin (Pyridoxal Phosphate phosphatase)

Template:ABSTRACT PUBMED 24338687

Function

[PLPP_MOUSE] Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP (By similarity).

About this Structure

4bx0 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kestler C, Knobloch G, Tessmer I, Jeanclos E, Schindelin H, Gohla A. Chronophin dimerization is required for proper positioning of its substrate specificity loop. J Biol Chem. 2013 Dec 14. PMID:24338687 doi:http://dx.doi.org/10.1074/jbc.M113.536482

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