3wkj
From Proteopedia
Contents |
The nucleosome containing human TSH2B
Function
[H2B1A_HUMAN] Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[1]
About this Structure
3wkj is a 10 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Jufvas A, Stralfors P, Vener AV. Histone variants and their post-translational modifications in primary human fat cells. PLoS One. 2011 Jan 7;6(1):e15960. doi: 10.1371/journal.pone.0015960. PMID:21249133 doi:http://dx.doi.org/10.1371/journal.pone.0015960
