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1tnd
From Proteopedia
Revision as of 20:39, 29 September 2014 by OCA (Talk | contribs)
1tnd is a 3 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic studies, suggests: how an activated receptor might open this cleft to allow nucleotide exchange; a mechanism for GTP-induced changes in effector and receptor binding surfaces; and a mechanism for GTPase activity not evident from previous data.
The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.,Noel JP, Hamm HE, Sigler PB Nature. 1993 Dec 16;366(6456):654-63. PMID:8259210[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Noel JP, Hamm HE, Sigler PB. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature. 1993 Dec 16;366(6456):654-63. PMID:8259210 doi:http://dx.doi.org/10.1038/366654a0
