1xe3
From Proteopedia
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Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis
Overview
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.
About this Structure
1XE3 is a Single protein structure of sequence from Bacillus anthracis with as ligand. Active as Purine-nucleoside phosphorylase, with EC number 2.4.2.1 Full crystallographic information is available from OCA.
Reference
Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis., Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:16511068
Page seeded by OCA on Thu Feb 21 15:53:48 2008
Categories: Bacillus anthracis | Purine-nucleoside phosphorylase | Single protein | Blagova, E V. | Brannigan, J A. | Fogg, M. | Grenha, R. | Levdikov, V M. | SPINE, Structural Proteomics in Europe. | Wilkinson, A J. | Wilson, K S. | CL | Deod | Purine nucleoside phosphorylase | Spine | Structural genomics | Structural proteomics in europe
