Publication Abstract from PubMed
The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.,Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:18084304[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
