4f22

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Template:STRUCTURE 4f22

Contents 1 Kainate bound to the K660A mutant of the ligand binding domain of GluA3 2 Function 3 About this Structure 4 See Also 5 Reference

Kainate bound to the K660A mutant of the ligand binding domain of GluA3

Template:ABSTRACT PUBMED 22512472

Function

[GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).

About this Structure

4f22 is a 1 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.

See Also

• Ionotropic Glutamate Receptors

Reference

• Holley SM, Ahmed AH, Srinivasan J, Murthy SE, Weiland GA, Oswald RE, Nowak LM. The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation. Biochemistry. 2012 May 15;51(19):4015-27. Epub 2012 May 2. PMID:22512472 doi:10.1021/bi3001837