4cid

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Template:STRUCTURE 4cid

Contents

Structural insights into the N-terminus of the EHD2 ATPase

Template:ABSTRACT PUBMED 24508342

Function

[EHD2_MOUSE] Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP.[1] [2]

About this Structure

4cid is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Shah C, Hegde BG, Moren B, Behrmann E, Mielke T, Moenke G, Spahn CM, Lundmark R, Daumke O, Langen R. Structural Insights into Membrane Interaction and Caveolar Targeting of Dynamin-like EHD2. Structure. 2014 Feb 4. pii: S0969-2126(14)00007-0. doi:, 10.1016/j.str.2013.12.015. PMID:24508342 doi:http://dx.doi.org/10.1016/j.str.2013.12.015
  1. ↑ Guilherme A, Soriano NA, Bose S, Holik J, Bose A, Pomerleau DP, Furcinitti P, Leszyk J, Corvera S, Czech MP. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem. 2004 Mar 12;279(11):10593-605. Epub 2003 Dec 15. PMID:14676205 doi:http://dx.doi.org/10.1074/jbc.M307702200
  2. ↑ Doherty KR, Demonbreun AR, Wallace GQ, Cave A, Posey AD, Heretis K, Pytel P, McNally EM. The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion. J Biol Chem. 2008 Jul 18;283(29):20252-60. Epub 2008 May 23. PMID:18502764 doi:http://dx.doi.org/M802306200

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