4n7q

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Template:STRUCTURE 4n7q

Contents

Crystal structure of eukaryotic THIC from A. thaliana

Template:ABSTRACT PUBMED 24161603

Function

[THIC_ARATH] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.[1] [2]

About this Structure

4n7q is a 1 chain structure with sequence from Arath. Full crystallographic information is available from OCA.

Reference

  • Coquille S, Roux C, Mehta A, Begley TP, Fitzpatrick TB, Thore S. High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana. J Struct Biol. 2013 Oct 23. pii: S1047-8477(13)00270-0. doi:, 10.1016/j.jsb.2013.10.005. PMID:24161603 doi:http://dx.doi.org/10.1016/j.jsb.2013.10.005
  1. ↑ Raschke M, Burkle L, Muller N, Nunes-Nesi A, Fernie AR, Arigoni D, Amrhein N, Fitzpatrick TB. Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19637-42. Epub 2007 Nov 28. PMID:18048325 doi:http://dx.doi.org/10.1073/pnas.0709597104
  2. ↑ Kong D, Zhu Y, Wu H, Cheng X, Liang H, Ling HQ. AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana. Cell Res. 2008 May;18(5):566-76. doi: 10.1038/cr.2008.35. PMID:18332905 doi:http://dx.doi.org/10.1038/cr.2008.35

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