2rtx

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Template:STRUCTURE 2rtx

Contents 1 Solution structure of the GGQ domain of YaeJ protein from Escherichia coli 2 Function 3 About this Structure 4 Reference

Solution structure of the GGQ domain of YaeJ protein from Escherichia coli

Template:ABSTRACT PUBMED 24322300

Function

[ARFB_ECOLI] Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters. May function as a complementary rescue system when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system or the alternative ribosome-rescue factor A.^{[1] [2]}

About this Structure

2rtx is a 1 chain structure. Full experimental information is available from OCA.

Reference

• Kogure H, Handa Y, Nagata M, Kanai N, Guntert P, Kubota K, Nameki N. Identification of residues required for stalled-ribosome rescue in the codon-independent release factor YaeJ. Nucleic Acids Res. 2013 Dec 9. PMID:24322300 doi:http://dx.doi.org/10.1093/nar/gkt1280

1. ↑ Chadani Y, Ono K, Kutsukake K, Abo T. Escherichia coli YaeJ protein mediates a novel ribosome-rescue pathway distinct from SsrA- and ArfA-mediated pathways. Mol Microbiol. 2011 May;80(3):772-85. doi: 10.1111/j.1365-2958.2011.07607.x. Epub, 2011 Mar 21. PMID:21418110 doi:http://dx.doi.org/10.1111/j.1365-2958.2011.07607.x
2. ↑ Handa Y, Inaho N, Nameki N. YaeJ is a novel ribosome-associated protein in Escherichia coli that can hydrolyze peptidyl-tRNA on stalled ribosomes. Nucleic Acids Res. 2011 Mar;39(5):1739-48. doi: 10.1093/nar/gkq1097. Epub 2010, Nov 3. PMID:21051357 doi:http://dx.doi.org/10.1093/nar/gkq1097