1arj
From Proteopedia
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ARG-BOUND TAR RNA, NMR
Overview
The human immunodeficiency virus type-1 (HIV-1) Tat protein stimulates, transcriptional elongation. Tat is introduced to the transcription, machinery by binding to the transactivation response region (TAR) RNA, stem-loop encoded by the 5' leader sequence found on all HIV-1 mRNAs. We, have used multidimensional heteronuclear NMR to determine the structure of, the TAR RNA in the presence of the ADP-1 polypeptide, a 37-mer that, carries the minimal RNA recognition region of the Tat protein and closely, mimics Tat binding specificity. In the presence of a variety of ligands, including ADP-1, related basic peptides and the amino acid derivative, argininamide, the bulge region of TAR undergoes a local conformational, rearrangement and forms a more stable structure. The structure of TAR in, the ... [(full description)]
About this Structure
1ARJ is a [Protein complex] structure of sequences from [[1]] with ARG as [ligand]. Structure known Active Site: TAR. Full crystallographic information is available from [OCA].
Reference
The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein., Aboul-ela F, Karn J, Varani G, J Mol Biol. 1995 Oct 20;253(2):313-32. PMID:7563092
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