4oca

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Template:STRUCTURE 4oca

Contents

Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N

Template:ABSTRACT PUBMED 24460375

Function

[F5ZUF5_SALTU] Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).[HAMAP-Rule:MF_01167][SAAS:SAAS022850_004_033570]

About this Structure

4oca is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Lee M, Sousa MC. Structural Basis for Substrate Specificity in ArnB. A Key Enzyme in the Polymyxin Resistance Pathway of Gram-Negative Bacteria. Biochemistry. 2014 Feb 4;53(4):796-805. doi: 10.1021/bi4015677. Epub 2014 Jan 24. PMID:24460375 doi:http://dx.doi.org/10.1021/bi4015677

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