4jh2

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Template:STRUCTURE 4jh2

Contents

Crystal Structure of FosB from Bacillus cereus with Zinc and Sulfate at 1.27 A Resolution

Template:ABSTRACT PUBMED 24004181

Function

[FOSB_BACC1] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).

About this Structure

4jh2 is a 2 chain structure with sequence from Bacc1. Full crystallographic information is available from OCA.

Reference

  • Thompson MK, Keithly ME, Harp J, Cook PD, Jagessar KL, Sulikowski GA, Armstrong RN. Structural and Chemical Aspects of Resistance to the Antibiotic Fosfomycin Conferred by FosB from Bacillus cereus. Biochemistry. 2013 Sep 30. PMID:24004181 doi:10.1021/bi4009648

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