1ziw
From Proteopedia
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Human Toll-like Receptor 3 extracellular domain structure
Overview
Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA.
About this Structure
1ZIW is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain., Choe J, Kelker MS, Wilson IA, Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:15961631
Page seeded by OCA on Thu Feb 21 16:16:00 2008
Categories: Homo sapiens | Single protein | Choe, J. | Wilson, I A. | GOL | NAG | NDG | SO4 | Innate immunity
