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2iut

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Revision as of 15:11, 30 October 2007 by OCA (Talk | contribs)
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Image:2iut.gif

2iut, resolution 2.25Å

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P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC

Overview

FtsK is a DNA translocase that coordinates chromosome segregation and cell, division in bacteria. In addition to its role as activator of XerCD, site-specific recombination, FtsK can translocate double-stranded DNA, (dsDNA) rapidly and directionally and reverse direction. We present, crystal structures of the FtsK motor domain monomer, showing that it has a, RecA-like core, the FtsK hexamer, and also showing that it is a ring with, a large central annulus and a dodecamer consisting of two hexamers, head, to head. Electron microscopy (EM) demonstrates the DNA-dependent existence, of hexamers in solution and shows that duplex DNA passes through the, middle of each ring. Comparison of FtsK monomer structures from two, different crystal forms highlights a conformational change that we ... [(full description)]

About this Structure

2IUT is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with MG and ATG as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635

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