4c10

From Proteopedia

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Template:STRUCTURE 4c10

Contents 1 Cryo-EM reconstruction of empty enterovirus 71 in complex with a neutralizing antibody E19 2 Function 3 About this Structure 4 Reference

Cryo-EM reconstruction of empty enterovirus 71 in complex with a neutralizing antibody E19

Template:ABSTRACT PUBMED 24469789

Function

[A9X4C2_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]

About this Structure

4c10 is a 6 chain structure with sequence from Human enterovirus 71 and Mus musculus. Full crystallographic information is available from OCA.

Reference

• Plevka P, Lim PY, Perera R, Cardosa J, Suksatu A, Kuhn RJ, Rossmann MG. Neutralizing antibodies can initiate genome release from human enterovirus 71. Proc Natl Acad Sci U S A. 2014 Jan 27. PMID:24469789 doi:http://dx.doi.org/10.1073/pnas.1320624111