1qqv is a 1 chain structure with sequence from Gallus gallus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
A growing family of F-actin-bundling proteins harbors a modular F-actin-binding headpiece domain at the C terminus. Headpiece provides one of the two F-actin-binding sites essential for filament bundling. Here, we report the first structure of a functional headpiece domain. The NMR structure of chicken villin headpiece (HP67) reveals two subdomains that share a tightly packed hydrophobic core. The N-terminal subdomain contains bends, turns, and a four-residue alpha-helix as well as a buried histidine residue that imparts a pH-dependent folding. The C-terminal subdomain is composed of three alpha-helices and its folding is pH-independent. Two residues previously implicated in F-actin-binding form a buried salt-bridge between the N and C-terminal subdomains. The rest of the identified actin-binding residues are solvent-exposed and map onto a unique F-actin-binding surface.
NMR structure of an F-actin-binding "headpiece" motif from villin.,Vardar D, Buckley DA, Frank BS, McKnight CJ J Mol Biol. 1999 Dec 17;294(5):1299-310. PMID:10600386[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Vardar D, Buckley DA, Frank BS, McKnight CJ. NMR structure of an F-actin-binding "headpiece" motif from villin. J Mol Biol. 1999 Dec 17;294(5):1299-310. PMID:10600386 doi:10.1006/jmbi.1999.3321
