4fvb

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Template:STRUCTURE 4fvb

Contents 1 Crystal structure of EV71 2A proteinase C110A mutant 2 Function 3 About this Structure 4 Reference

Crystal structure of EV71 2A proteinase C110A mutant

Template:ABSTRACT PUBMED 23616646

Function

[A9XG43_9ENTO] Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities (By similarity).[SAAS:SAAS000199_004_016611] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266] RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]

About this Structure

4fvb is a 1 chain structure with sequence from Enterovirus a71. Full crystallographic information is available from OCA.

Reference

• Cai Q, Yameen M, Liu W, Gao Z, Li Y, Peng X, Cai Y, Wu C, Zheng Q, Li J, Lin T. Conformational Plasticity of 2A Proteinase from Enterovirus 71. J Virol. 2013 Apr 24. PMID:23616646 doi:10.1128/JVI.03541-12