4miw
From Proteopedia
Contents |
High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase
Template:ABSTRACT PUBMED 24516554
Function
[Q6GWS2_9VIRU] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]
About this Structure
4miw is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Wallat GD, Huang Q, Wang W, Dong H, Ly H, Liang Y, Dong C. High-resolution structure of the N-terminal endonuclease domain of the lassa virus L polymerase in complex with magnesium ions. PLoS One. 2014 Feb 7;9(2):e87577. doi: 10.1371/journal.pone.0087577. eCollection , 2014. PMID:24516554 doi:http://dx.doi.org/10.1371/journal.pone.0087577
