4a13

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Template:STRUCTURE 4a13

Contents

model refined against symmetry-free cryo-EM map of TRiC-ADP

Template:ABSTRACT PUBMED 22045336

Function

[TCPB_BOVIN] Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).

About this Structure

4a13 is a 16 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Cong Y, Schroder GF, Meyer AS, Jakana J, Ma B, Dougherty MT, Schmid MF, Reissmann S, Levitt M, Ludtke SL, Frydman J, Chiu W. Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. EMBO J. 2011 Nov 1;31(3):720-30. doi: 10.1038/emboj.2011.366. PMID:22045336 doi:10.1038/emboj.2011.366

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