4je6

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Template:STRUCTURE 4je6

Contents 1 Crystal structure of a human-like mitochondrial peptide deformylase 2 Function 3 About this Structure 4 Reference

Crystal structure of a human-like mitochondrial peptide deformylase

Template:ABSTRACT PUBMED 24531459

Function

[DEF1A_ARATH] Removes the formyl group from the N-terminal Met of newly synthesized proteins.^[1]

About this Structure

4je6 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

• Fieulaine S, Desmadril M, Meinnel T, Giglione C. Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):242-52. doi:, 10.1107/S1399004713026461. Epub 2014 Jan 17. PMID:24531459 doi:http://dx.doi.org/10.1107/S1399004713026461

1. ↑ Giglione C, Serero A, Pierre M, Boisson B, Meinnel T. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms. EMBO J. 2000 Nov 1;19(21):5916-29. PMID:11060042 doi:10.1093/emboj/19.21.5916