2a6d

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Image:2a6d.gif

2a6d, resolution 2.9Å

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Crystal structure analysis of the anti-arsonate germline antibody 36-65 in complex with a phage display derived dodecapeptide RLLIADPPSPRE

Overview

The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.

About this Structure

2A6D is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Multiple paths to multispecificity., Mariuzza RA, Immunity. 2006 Apr;24(4):359-61. PMID:16618592

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