4bi2

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Template:STRUCTURE 4bi2

Contents

Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor

Template:ABSTRACT PUBMED 23672464

Function

[TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.[1]

About this Structure

4bi2 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Langdon SR, Westwood IM, van Montfort RL, Brown N, Blagg J. Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors. J Chem Inf Model. 2013 May 24;53(5):1100-12. doi: 10.1021/ci400100c. Epub 2013, May 14. PMID:23672464 doi:10.1021/ci400100c
  1. ↑ Jelluma N, Brenkman AB, van den Broek NJ, Cruijsen CW, van Osch MH, Lens SM, Medema RH, Kops GJ. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell. 2008 Jan 25;132(2):233-46. doi: 10.1016/j.cell.2007.11.046. PMID:18243099 doi:10.1016/j.cell.2007.11.046

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