4lqy

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Template:STRUCTURE 4lqy

Contents

Crystal Structure of Human ENPP4 with AMP

Template:ABSTRACT PUBMED 24338010

Function

[ENPP4_HUMAN] Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.[1]

About this Structure

4lqy is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM, Braddock DT. Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem. 2014 Feb 7;289(6):3294-306. doi: 10.1074/jbc.M113.505867. Epub 2013 , Dec 12. PMID:24338010 doi:http://dx.doi.org/10.1074/jbc.M113.505867
  1. ↑ Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22;120(22):4432-40. doi: 10.1182/blood-2012-04-425215. Epub 2012 , Sep 20. PMID:22995898 doi:http://dx.doi.org/10.1182/blood-2012-04-425215

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