4bfm

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Template:STRUCTURE 4bfm

Contents 1 The crystal structure of mouse PK38 2 Function 3 About this Structure 4 Reference

The crystal structure of mouse PK38

Template:ABSTRACT PUBMED 24531485

Function

[MELK_MOUSE] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.^{[1] [2]}

About this Structure

4bfm is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Cho YS, Yoo J, Park S, Cho HS. The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):514-21. doi:, 10.1107/S1399004713027806. Epub 2014 Jan 31. PMID:24531485 doi:http://dx.doi.org/10.1107/S1399004713027806

1. ↑ Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005 Aug 1;170(3):413-27. PMID:16061694 doi:http://dx.doi.org/10.1083/jcb.200412115
2. ↑ Jung H, Seong HA, Ha H. Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. J Biol Chem. 2008 Dec 12;283(50):34541-53. doi: 10.1074/jbc.M807219200. Epub 2008, Oct 23. PMID:18948261 doi:http://dx.doi.org/10.1074/jbc.M807219200