4hof

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Template:STRUCTURE 4hof

Contents

Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H)

Template:ABSTRACT PUBMED 24568657

Function

[DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

About this Structure

4hof is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC. Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J Med Chem. 2014 Mar 6. PMID:24568657 doi:http://dx.doi.org/10.1021/jm401916j

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