4jhr

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Template:STRUCTURE 4jhr

Contents

An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs

Template:ABSTRACT PUBMED 23665171

Function

[GPSM2_MOUSE] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.

About this Structure

4jhr is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Pan Z, Zhu J, Shang Y, Wei Z, Jia M, Xia C, Wen W, Wang W, Zhang M. An Autoinhibited Conformation of LGN Reveals a Distinct Interaction Mode between GoLoco Motifs and TPR Motifs. Structure. 2013 Jun 4;21(6):1007-17. doi: 10.1016/j.str.2013.04.005. Epub 2013, May 9. PMID:23665171 doi:10.1016/j.str.2013.04.005

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OCA

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