4iz6

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Template:STRUCTURE 4iz6

Contents

Structure of EntE and EntB, an NRPS adenylation-PCP fusion protein with pseudo translational symmetry

Template:ABSTRACT PUBMED 23897471

Function

[ENTE_ECOLI] Activates the carboxylate group of 2,3-dihydroxy-benzoate (2,3-DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate. Then, catalyzes the acylation of holo-EntB with 2,3-DHB adenylate, preparing that molecule for amide bond formation with L-serine.

About this Structure

4iz6 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Sundlov JA, Gulick AM. Structure determination of the functional domain interaction of a chimeric nonribosomal peptide synthetase from a challenging crystal with noncrystallographic translational symmetry. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1482-92. doi:, 10.1107/S0907444913009372. Epub 2013 Jul 18. PMID:23897471 doi:http://dx.doi.org/10.1107/S0907444913009372

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