4j9j

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Template:STRUCTURE 4j9j

Contents

Structure of designed HisF

Template:ABSTRACT PUBMED 23806364

Function

[HIS6_THEMA] IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.[HAMAP-Rule:MF_01013]

About this Structure

4j9j is a 1 chain structure with sequence from Thermotoga maritima msb8. Full crystallographic information is available from OCA.

Reference

  • Sperl JM, Rohweder B, Rajendran C, Sterner R. Establishing catalytic activity on an artificial (betaalpha)-barrel protein designed from identical half-barrels. FEBS Lett. 2013 Jun 24. pii: S0014-5793(13)00469-9. doi:, 10.1016/j.febslet.2013.06.022. PMID:23806364 doi:10.1016/j.febslet.2013.06.022

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