3hw2

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Template:STRUCTURE 3hw2

Contents

Crystal structure of the SifA-SKIP(PH) complex

Template:ABSTRACT PUBMED 19801640

Function

[SIFA_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication.[1] [2] [3] [PKHM2_HUMAN] May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation.[4]

About this Structure

3hw2 is a 2 chain structure with sequence from Human and Salty. Full crystallographic information is available from OCA.

Reference

  • Diacovich L, Dumont A, Lafitte D, Soprano E, Guilhon AA, Bignon C, Gorvel JP, Bourne Y, Meresse S. Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis. J Biol Chem. 2009 Nov 27;284(48):33151-60. Epub 2009 Sep 28. PMID:19801640 doi:10.1074/jbc.M109.034975
  1. ↑ Brumell JH, Goosney DL, Finlay BB. SifA, a type III secreted effector of Salmonella typhimurium, directs Salmonella-induced filament (Sif) formation along microtubules. Traffic. 2002 Jun;3(6):407-15. PMID:12010459
  2. ↑ Boucrot E, Henry T, Borg JP, Gorvel JP, Meresse S. The intracellular fate of Salmonella depends on the recruitment of kinesin. Science. 2005 May 20;308(5725):1174-8. PMID:15905402 doi:308/5725/1174
  3. ↑ Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI. Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. Cell Host Microbe. 2008 Nov 13;4(5):434-46. PMID:18996344 doi:S1931-3128(08)00291-6
  4. ↑ Boucrot E, Henry T, Borg JP, Gorvel JP, Meresse S. The intracellular fate of Salmonella depends on the recruitment of kinesin. Science. 2005 May 20;308(5725):1174-8. PMID:15905402 doi:308/5725/1174

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