Structural highlights
2w1b is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | |
| Related: | 1oy8, 1t9u, 1iwg, 1t9t, 1t9y, 1t9w, 2j8s, 1oy6, 1t9x, 2gif, 2hrt, 1oye, 1oyd, 1oy9, 1t9v |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.
The structure of the efflux pump AcrB in complex with bile acid.,Drew D, Klepsch MM, Newstead S, Flaig R, De Gier JW, Iwata S, Beis K Mol Membr Biol. 2008 Dec;25(8):677-82. PMID:19023693[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Drew D, Klepsch MM, Newstead S, Flaig R, De Gier JW, Iwata S, Beis K. The structure of the efflux pump AcrB in complex with bile acid. Mol Membr Biol. 2008 Dec;25(8):677-82. PMID:19023693 doi:905752382
