4jbk

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Template:STRUCTURE 4jbk

Contents 1 Molecular basis for abrogation of activation of pro-inflammatory cytokines 2 Function 3 About this Structure 4 Reference

Molecular basis for abrogation of activation of pro-inflammatory cytokines

Function

[IFI2_MOUSE] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.^{[1] [2]}

About this Structure

4jbk is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

• Ru H, Ni X, Zhao L, Crowley C, Ding W, Hung LW, Shaw N, Cheng G, Liu ZJ. Structural basis for termination of AIM2-mediated signaling by p202. Cell Res. 2013 Jun;23(6):855-8. doi: 10.1038/cr.2013.52. Epub 2013 Apr 9. PMID:23567559 doi:10.1038/cr.2013.52

1. ↑ Xin H, D'Souza S, Jorgensen TN, Vaughan AT, Lengyel P, Kotzin BL, Choubey D. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006 May 15;176(10):5863-70. PMID:16670293
2. ↑ Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA, Stacey KJ. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009 Feb 20;323(5917):1057-60. doi: 10.1126/science.1169841. Epub 2009, Jan 8. PMID:19131592 doi:10.1126/science.1169841