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Template:STRUCTURE 3id5

Contents 1 Crystal structure of Sulfolobus solfataricus C/D RNP assembled with Nop5, fibrillarin, L7Ae and a split half C/D RNA 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of Sulfolobus solfataricus C/D RNP assembled with Nop5, fibrillarin, L7Ae and a split half C/D RNA

Template:ABSTRACT PUBMED 19666563

Function

[RL7A_SULSO] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). [FLPA_SULSO] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.^{[1] [2]}

About this Structure

3id5 is a 8 chain structure with sequence from Atcc 35091. Full crystallographic information is available from OCA.

See Also

• Aldehyde dehydrogenase
• Ribosomal protein L7

Reference

• Ye K, Jia R, Lin J, Ju M, Peng J, Xu A, Zhang L. Structural organization of box C/D RNA-guided RNA methyltransferase. Proc Natl Acad Sci U S A. 2009 Aug 5. PMID:19666563

1. ↑ Omer AD, Ziesche S, Ebhardt H, Dennis PP. In vitro reconstitution and activity of a C/D box methylation guide ribonucleoprotein complex. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5289-94. PMID:11959980 doi:http://dx.doi.org/10.1073/pnas.082101999
2. ↑ Ziesche SM, Omer AD, Dennis PP. RNA-guided nucleotide modification of ribosomal and non-ribosomal RNAs in Archaea. Mol Microbiol. 2004 Nov;54(4):980-93. PMID:15522081 doi:http://dx.doi.org/MMI4319