4k5h

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Template:STRUCTURE 4k5h

Contents

Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-1,2-bis((2-amino-4-methylpyridin-6-yl)-methoxy)-propan-3-amine

Template:ABSTRACT PUBMED 23993333

Function

[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

About this Structure

4k5h is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

  • Jing Q, Li H, Chreifi G, Roman LJ, Martasek P, Poulos TL, Silverman RB. Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5674-9. doi: 10.1016/j.bmcl.2013.08.034., Epub 2013 Aug 14. PMID:23993333 doi:10.1016/j.bmcl.2013.08.034

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