2bkt

From Proteopedia

Revision as of 14:38, 21 February 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:2bkt.gif

2bkt, resolution 2.3Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF RENIN-PF00257567 COMPLEX

Contents

Overview

We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.

Disease

Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]

About this Structure

2BKT is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Renin, with EC number 3.4.23.15 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors., Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4. PMID:15837327

Page seeded by OCA on Thu Feb 21 16:38:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bkt"
Personal tools