4npl

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Template:STRUCTURE 4npl

Contents

Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate

Template:ABSTRACT PUBMED 24561204

Function

[ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).

About this Structure

4npl is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Chen W, Zhang L, Zheng G, Fu Y, Ji Q, Liu F, Chen H, He C. Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett. 2014 Mar 18;588(6):892-8. doi: 10.1016/j.febslet.2014.02.021. Epub, 2014 Feb 20. PMID:24561204 doi:http://dx.doi.org/10.1016/j.febslet.2014.02.021

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