3wdc

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3wdc

Contents 1 N-terminal domain of Mycobacterium tuberculosis ClpC1 bound to Cyclomarin A 2 Function 3 About this Structure 4 Reference

N-terminal domain of Mycobacterium tuberculosis ClpC1 bound to Cyclomarin A

Template:ABSTRACT PUBMED 24022489

Function

[CLPC1_MYCTU] ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity). Degrades anti-sigma-E factor RseA in the presence of ClpP2.

About this Structure

3wdc is a 2 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884 and Chainia sp.. Full crystallographic information is available from OCA.

Reference

• Vasudevan D, Rao SP, Noble CG. Structural basis of mycobacterial inhibition by cyclomarin A. J Biol Chem. 2013 Oct 25;288(43):30883-91. doi: 10.1074/jbc.M113.493767. Epub, 2013 Sep 10. PMID:24022489 doi:http://dx.doi.org/10.1074/jbc.M113.493767