3oqc

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Template:STRUCTURE 3oqc

Contents

Ubiquitin-fold modifier 1 Specific Protease, UfSP2

Template:ABSTRACT PUBMED 21228277

Function

[UFSP2_MOUSE] Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins.[1] [2]

About this Structure

3oqc is a 2 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

Reference

  • Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, Watson CM, Wallis G, Chung CH, Kim EE. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. J Biol Chem. 2011 Mar 25;286(12):10248-57. Epub 2011 Jan 12. PMID:21228277 doi:http://dx.doi.org/10.1074/jbc.M110.172171
  1. ↑ Kang SH, Kim GR, Seong M, Baek SH, Seol JH, Bang OS, Ovaa H, Tatsumi K, Komatsu M, Tanaka K, Chung CH. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. J Biol Chem. 2007 Feb 23;282(8):5256-62. Epub 2006 Dec 20. PMID:17182609 doi:http://dx.doi.org/M610590200
  2. ↑ Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, Watson CM, Wallis G, Chung CH, Kim EE. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. J Biol Chem. 2011 Mar 25;286(12):10248-57. Epub 2011 Jan 12. PMID:21228277 doi:http://dx.doi.org/10.1074/jbc.M110.172171

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