4i02

From Proteopedia

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Template:STRUCTURE 4i02

Contents 1 structure of the mutant Catabolite gene activator protein V140A 2 Function 3 About this Structure 4 Reference

structure of the mutant Catabolite gene activator protein V140A

Template:ABSTRACT PUBMED 24058293

Function

[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.^[1]

About this Structure

4i02 is a 6 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

Reference

• Rodgers TL, Townsend PD, Burnell D, Jones ML, Richards SA, McLeish TC, Pohl E, Wilson MR, Cann MJ. Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors. PLoS Biol. 2013 Sep;11(9):e1001651. doi: 10.1371/journal.pbio.1001651. Epub 2013 , Sep 10. PMID:24058293 doi:http://dx.doi.org/10.1371/journal.pbio.1001651

1. ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847