4gfc

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Template:STRUCTURE 4gfc

Contents 1 N-terminal coiled-coil dimer of C.elegans SAS-6, crystal form B 2 Function 3 About this Structure 4 Reference

N-terminal coiled-coil dimer of C.elegans SAS-6, crystal form B

Template:ABSTRACT PUBMED 23798409

Function

[SAS6_CAEEL] Required for centrosome duplication. Participates in centriole assembly.^{[1] [2]}

About this Structure

4gfc is a 2 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

• Hilbert M, Erat MC, Hachet V, Guichard P, Blank ID, Fluckiger I, Slater L, Lowe ED, Hatzopoulos GN, Steinmetz MO, Gonczy P, Vakonakis I. Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11373-8. doi:, 10.1073/pnas.1302721110. Epub 2013 Jun 24. PMID:23798409 doi:10.1073/pnas.1302721110

1. ↑ Dammermann A, Muller-Reichert T, Pelletier L, Habermann B, Desai A, Oegema K. Centriole assembly requires both centriolar and pericentriolar material proteins. Dev Cell. 2004 Dec;7(6):815-29. PMID:15572125 doi:S1534580704003806
2. ↑ Leidel S, Delattre M, Cerutti L, Baumer K, Gonczy P. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nat Cell Biol. 2005 Feb;7(2):115-25. PMID:15665853 doi:ncb1220