| Structural highlights
2xjw is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , , |
| Related: | 1w6z, 1kxx, 4lyo, 3lyo, 1kip, 1t6v, 1vds, 1ic7, 1lzt, 1kir, 2xbr, 1lys, 132l, 1e8l, 1bwj, 1yil, 1heo, 1sfg, 1kxw, 2x0a, 2c8o, 1g7l, 1yl1, 1sf4, 1ior, 1h87, 1ljg, 3lyt, 1iot, 1dpx, 1v7s, 1ja6, 1jis, 1ir8, 2w1m, 1uic, 1ykz, 1xgq, 1uie, 2war, 1lji, 1lj3, 1dpw, 8lyz, 1bwi, 2iff, 2lyo, 1g7h, 1lks, 1jj0, 1rfp, 5lyt, 1sfb, 1jiy, 1ir7, 1iee, 1xei, 1hel, 1xek, 1at6, 1ljf, 1mlc, 2b5z, 1f10, 1lsz, 193l, 1ljk, 6lyt, 1sq2, 1vdq, 1zmy, 1lje, 2xth, 2d91, 1lze, 1b2k, 1aki, 1uia, 1hen, 1yik, 1xfp, 2d6b, 1ndg, 1lpi, 1lsd, 1flw, 2blx, 6lyz, 1nbz, 1lsg, 4lyt, 3hfm, 1ved, 1jit, 1lzn, 1wtn, 1ja2, 1uuz, 1lyz, 2d4i, 2xbs, 2fbb, 1fdl, 2lym, 1gxx, 1lz9, 1lse, 1lzh, 1lsm, 1jj3, 7lyz, 3lym, 1yky, 1kiq, 1t3p, 1heq, 2lzh, 1uih, 1kxy, 2w1l, 1g7j, 1b0d, 2bly, 1her, 1bhz, 1wtm, 1nby, 1ioq, 1hep, 1jtt, 1qio, 1lza, 1xgp, 1ps5, 1gwd, 1jpo, 1v7t, 1h6m, 1dqj, 1j1p, 2a7d, 1ljj, 1z55, 2c8p, 1lsb, 1f0w, 2w1x, 1flq, 1lzg, 1lzc, 1jj1, 1rcm, 1uid, 1yqv, 1bgi, 1hsx, 1lzd, 1lcn, 1hew, 2cds, 2vb1, 2aub, 1uib, 1hf4, 1j1x, 1ios, 1rjc, 2cgi, 1ir9, 1uc0, 1azf, 1ic4, 1ljh, 4lyz, 1gpq, 2a6u, 2d4k, 1xej, 1ja7, 1mel, 1ri8, 1uig, 1bvx, 1qtk, 1c10, 1lkr, 1lyo, 1n4f, 1hsw, 1g7m, 2w1y, 1jto, 1sf7, 1lsf, 1fn5, 2d4j, 5lyz, 3lzt, 1c08, 1ndm, 1sf6, 3lyz, 1bvk, 1uif, 1vau, 2lyz, 1lma, 1fly, 1hc0, 1j1o, 1yl0, 2lzt, 1a2y, 4lzt, 1lsy, 1uco, 1gxv, 1ic5, 1lsa, 1p2c, 5lym, 1ua6, 1at5, 1vat, 1lj4, 1f3j, 1hem, 1vfb, 1ja4, 2a7f, 4lym, 194l, 1flu, 1lz8, 1ykx, 1vdt, 2hfm, 1bwh, 1io5, 1lsn, 1lzb, 2bpu, 1g7i, 1lsc, 1vdp |
| Activity: | Lysozyme, with EC number 3.2.1.17 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
CORM-3, [fac-Ru(CO)(3)Cl(kappa(2)-H(2)NCH(2)CO(2))], is a well-known carbon monoxide releasing molecule (CORM) capable of delivering CO in vivo. Herein we show for the first time that the interactions of CORM-3 with proteins result in the loss of a chloride ion, glycinate, and one CO ligand. The rapid formation of stable adducts between the protein and the remaining cis-Ru(II)(CO)(2) fragments was confirmed by Inductively Coupled Plasma-Atomic Emission Spectrocopy (ICP-AES), Liquid-Chromatography Mass Spectrometry (LC-MS), Infrared Spectroscopy (IR), and X-ray crystallography. Three Ru coordination sites are observed in the structure of hen egg white lysozyme crystals soaked with CORM-3. The site with highest Ru occupancy (80%) shows a fac-[(His15)Ru(CO)(2)(H(2)O)(3)] structure.
CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysozyme Complex.,Santos-Silva T, Mukhopadhyay A, Seixas JD, Bernardes GJ, Romao CC, Romao MJ J Am Chem Soc. 2011 Jan 4. PMID:21204537[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Santos-Silva T, Mukhopadhyay A, Seixas JD, Bernardes GJ, Romao CC, Romao MJ. CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysozyme Complex. J Am Chem Soc. 2011 Jan 4. PMID:21204537 doi:10.1021/ja108820s
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