3gnw
From Proteopedia
Contents |
HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 4c
Template:ABSTRACT PUBMED 19507864
About this Structure
3gnw is a 2 chain structure with sequence from Hepatitis c virus isolate hc-j4. Full crystallographic information is available from OCA.
See Also
Reference
- Vandyck K, Cummings MD, Nyanguile O, Boutton CW, Vendeville S, McGowan D, Devogelaere B, Amssoms K, Last S, Rombauts K, Tahri A, Lory P, Hu L, Beauchamp DA, Simmen K, Raboisson P. Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase. J Med Chem. 2009 Jul 23;52(14):4099-102. PMID:19507864 doi:10.1021/jm9005548
Categories: Hepatitis c virus isolate hc-j4 | RNA-directed RNA polymerase | Bondt, H De. | Nyanguile, O. | 5-benzodiazepine | Apoptosis | Atp-binding | Capsid protein | Cell membrane | Endoplasmic reticulum | Envelope protein | Fusion protein | Glycoprotein | Helicase | Hepatitis c virus | Host-virus interaction | Hydrolase | Interferon antiviral system evasion | Lipid droplet | Lipoprotein | Membrane | Metal-binding | Mitochondrion | Multifunctional enzyme | Ns5b | Nucleotide-binding | Nucleotidyltransferase | Nucleus | Oncogene | Palmitate | Phosphoprotein | Polymerase | Protease | Ribonucleoprotein | Rna replication | Rna-binding | Rna-directed rna polymerase | Secreted | Serine protease | Sh3-binding | Sulfone | Thiol protease | Transcription | Transcription regulation | Transferase | Transmembrane | Viral nucleoprotein | Virion
