| Structural highlights
2yat is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Ligands: | , , |
| Related: | 1xp1, 1qkt, 1r5k, 1zky, 2bj4, 1hcp, 1akf, 1hcq, 1a52, 1qku, 1xp6, 1g50, 1pcg, 2jf9, 2b1v, 1uom, 1yim, 2ayr, 3ert, 1yin, 1err, 1x7r, 3erd, 1l2i, 2fai, 1xp9, 2jfa, 1gwr, 1sj0, 1gwq, 1xpc, 1x7e, 1xqc, 1ere |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Publication Abstract from PubMed
Selective estrogen receptor modulators, such as estradiol 17alpha-derived metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. Here, we report the detailed 3D structure of estrogen receptor alpha ligand-binding domain (ERalpha-LBD) bound with a novel estradiol-derived metal complex, estradiol-pyridine tetra acetate europium (III) at 2.6A resolution. This structure provides important information pertinent to the design of novel functional ERalpha targeted probes for clinical applications.
Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators.,Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL J Med Chem. 2011 Apr 7. PMID:21473635[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators. J Med Chem. 2011 Apr 7. PMID:21473635 doi:10.1021/jm200192y
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