1jow is a 2 chain structure with sequence from Homo sapiens and Saimiriine herpesvirus 2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Cyclin from herpesvirus saimiri (Vcyclin) preferentially forms complexes with cyclin-dependent kinase 6 (CDK6) from primate host cells. These complexes show higher kinase activity than host cell CDKs in complex with cellular cyclins and are resistant to cyclin-dependent inhibitory proteins (CDKIs). The crystal structure of human CDK6--Vcyclin in an active state was determined to 3.1 A resolution to better understand the structural basis of CDK6 activation by viral cyclins. The unphosphorylated CDK6 in complex with Vcyclin has many features characteristic of cyclinA-activated, phosphorylated CDK2. There are, however, differences in the conformation at the tip of the T-loop and its interactions with Vcyclin. Residues in the N-terminal extension of Vcyclin wrap around the tip of the CDK6 T-loop and form a short beta-sheet with the T-loop backbone. These interactions lead to a 20% larger buried surface in the CDK6--Vcyclin interface than in the CDK2--cyclinA complex and are probably largely responsible for the specificity of Vcyclin for CDK6 and resistance of the complex to inhibition by INK-type CDKIs.
Structural basis for CDK6 activation by a virus-encoded cyclin.,Schulze-Gahmen U, Kim SH Nat Struct Biol. 2002 Mar;9(3):177-81. PMID:11828325[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
↑ Schulze-Gahmen U, Kim SH. Structural basis for CDK6 activation by a virus-encoded cyclin. Nat Struct Biol. 2002 Mar;9(3):177-81. PMID:11828325 doi:10.1038/nsb756
