4nc5

From Proteopedia

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Template:STRUCTURE 4nc5

Contents 1 Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate) 2 Function 3 About this Structure 4 See Also 5 Reference

Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)

Template:ABSTRACT PUBMED 24591206

Function

[NEUR2_HUMAN] Hydrolyzes sialylated compounds.

About this Structure

4nc5 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

See Also

• Neuraminidase

Reference

• Buchini S, Gallat FX, Greig IR, Kim JH, Wakatsuki S, Chavas LM, Withers SG. Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights. Angew Chem Int Ed Engl. 2014 Mar 24;53(13):3382-6. doi: 10.1002/anie.201309675., Epub 2014 Mar 3. PMID:24591206 doi:http://dx.doi.org/10.1002/anie.201309675