4lf3

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Template:STRUCTURE 4lf3

Contents

Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor

Template:ABSTRACT PUBMED 24189067

Function

[GLR_HUMAN] This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

About this Structure

4lf3 is a 6 chain structure with sequence from Human and Lk3 transgenic mice. Full crystallographic information is available from OCA.

Reference

  • Mukund S, Shang Y, Clarke HJ, Madjidi A, Corn JE, Kates L, Kolumam G, Chiang V, Luis E, Murray J, Zhang Y, Hotzel I, Koth CM, Allan BB. Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor. J Biol Chem. 2013 Nov 4. PMID:24189067 doi:http://dx.doi.org/10.1074/jbc.M113.496984

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